Abstract
Sleep is largely regulated by the light-dark cycle and associated circadian rhythms. Poor health outcomes are known to be associated with poor sleep quality and sleep deprivation. Sleep quality and sleep disorders affect symptom manifestation and have been implicated in increasing risk of medical conditions like hypertension, obesity, stroke, and heart disease and increased overall mortality. Recent studies have suggested that there is a strong association between sleep disturbances and gastrointestinal diseases like gastroesophageal reflux disease, peptic ulcer disease, irritable bowel syndrome, etc. It is important for gastroenterologists as well as sleep physicians to be aware of the relationship between sleep disorders and gastrointestinal illnesses to ensure good care for patients. Currently, most literature on sleep disorders in GI diseases is based on subjective parameters, and limited information is available on objective criteria like polysomnography.
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References
Colten HR, Altevogt BM, editors. Sleep disorders and sleep deprivation: an unmet public health problem. Washington, DC: National Academies Press; 2006. http://www.ncbi.nlm.nih.gov/books/NBK19960/
Balkin TJ, Rupp T, Picchioni D, Wesensten NJ. Sleep loss and sleepiness: current issues. Chest. 2008;134(3):653–60.
Ali T, Choe J, Awab A, Wagener TL, Orr WC. Sleep, immunity and inflammation in gastrointestinal disorders. World J Gastroenterol. 2013;19(48):9231–9.
Ranjbaran Z, Keefer L, Farhadi A, Stepanski E, Sedghi S, Keshavarzian A. Impact of sleep disturbances in inflammatory bowel disease. J Gastroenterol Hepatol. 2007;22(11):1748–53.
Chen MJ, Wu MS, Lin JT, et al. Gastroesophageal reflux disease and sleep quality in a Chinese population. J Formos Med Assoc. 2009;108(1):53–60.
Ananthakrishnan AN, Long MD, Martin CF, Sandler RS, Kappelman MD. Sleep disturbance and risk of active disease in patients with Crohn’s disease and ulcerative colitis. Clin Gastroenterol Hepatol. 2013;11(8):965–71.
Nojkov B, Rubenstein JH, Chey WD, Hoogerwerf WA. The impact of rotating shift work on the prevalence of irritable bowel syndrome in nurses. Am J Gastroenterol. 2010;105:842–7.
Córdoba J, Cabrera J, Lataif L, Penev P, Zee P, Blei AT. High prevalence of sleep disturbance in cirrhosis. Hepatology. 1998;27(2):339–45.
Dawes C. Circadian rhythms in human salivary flow rate and composition. J Physiol. 1972;220:529–45.
Hoogerwerf WA. Role of clock genes in gastrointestinal motility. Am J Physiol Gastrointest Liver Physiol. 2010;299:G549–55.
Pácha J, Sumová A. Circadian regulation of epithelial functions in the intestine. Acta Physiol (Oxf). 2013;208:11–24.
Ferrell JM, Chiang JY. Circadian rhythms in liver metabolism and disease. Acta Pharm Sin B. 2015;5:113–22.
Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015;28(2):203–9.
Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R. Global consensus group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101(8):1900–20.
Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010. JAMA. 2012;307(5):491–7.
Iorgulescu G. Saliva between normal and pathological. Important factors in determining systemic and oral health. J Med Life. 2009;2(3):303–7.
Lear CS, Flanagan JB Jr, Moorrees CF. The frequency of deglutition in man. Arch Oral Biol. 1965;10:83–100.
Kanaly T, Shaheen NJ, Vaughn BV. Gastrointestinal physiology and digestive disorders in sleep. Curr Opin Pulm Med. 2009;15(6):571–7.
Fass R. Effect of gastroesophageal reflux disease on sleep. J Gastroenterol Hepatol. 2010;25(suppl 1):S41–4.
Fass R. The relationship between gastroesophageal reflux disease and sleep. Curr Gastroenterol Rep. 2009;11:202–8.
Schmid SM, Hallschmid M, JauchChara K, Born J, Schultes B. A single night of sleep deprivation increases ghrelin levels and feelings of hunger in normal weight healthy men. J Sleep Res. 2008;17:331–4.
Gerson LB, Fass R. A systematic review of the definitions, prevalence, and response to treatment of nocturnal gastroesophageal reflux disease. Clin Gastroenterol Hepatol. 2009;7:372–8.
Shaker R, Brunton S, Elfant A, Golopol L, Ruoff G, Stanghellini V. Review article: impact of nighttime reflux on lifestyle— unrecognized issues in reflux disease. Aliment Pharmacol Ther. 2004;20(suppl 9):3–13.
Farup C, Kleinman L, Sloan S, et al. The impact of nocturnal symptoms associated with gastroesophageal reflux disease on health related quality of life. Arch Intern Med. 2001;161:45–52.
Shaker R, Castell DO, Schoenfeld PS, Spechler SJ. Night time heartburn is an underappreciated clinical problem that impacts sleep and daytime function: the results of a Gallup survey conducted on behalf of the American Gastroenterological Association. Am J Gastroenterol. 2003;98:1487–93.
Locke GR 3rd, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ 3rd. Prevalence and clinical spectrum of gastroesophageal reflux: a population basedstudy in Olmsted County, Minnesota. Gastroenterology. 1997;112:1448–56.
Fass R, Quan SF, O’Connor GT, Ervin A, Iber C. Predictors of heartburn during sleep in a large prospective cohort study. Chest. 2005;127:1658–66.
Dean BB, Aguilar D, Johnson LF, et al. Night-time and daytime atypical manifestations of gastro oesophageal reflux disease: frequency, severity and impact on health related quality of life. Aliment Pharmacol Ther. 2008;27:327–37.
Gislason T, Janson C, Vermeire P, et al. Respiratory symptoms and nocturnal gastroesophageal reflux: a population based study of young adults in three European countries. Chest. 2002;121:158–63.
Graf KI, Karaus M, Heinemann S, Korber S, Dorow P, Hampel KE. Gastroesophageal reflux in patients with sleep apnea syndrome. Z Gastroenterol. 1995;33:689–93.
Sabate JM, Jouet P, Merrouche M, et al. Gastroesophageal reflux in patients with morbid obesity: a role of obstructive sleep apnea syndrome? Obes Surg. 2008;18:1479–84.
Green BT, Broughton WA, O’Connor B. Marked improvement in nocturnal gastroesophageal reflux in a large cohort of patients with obstructive sleep apnea treated with continuous positive airway pressure. Arch Intern Med. 2003;163:41–5.
Shepherd K, James A, Musk A, Hunter M, Hillman D, Eastwood P. Gastroesophageal reflux symptoms are related to the presence and severity of obstructive sleep apnea. J Sleep Res. 2010;20:241–9.
Shepherd K, Orr W. Mechanism of gastroesophageal reflux in obstructive sleep apnea: airway obstruction or obesity? J Clin Sleep Med. 2016;12(1):87–94.
Stanghellini V, Chan FK, Hasler WL, Malagelada JR, Suzuki H, Tack J, Talley NJ. Gastroenterology. 2016;150(6):1380–92.
Vanheel H, Carbone F, Valvekens L, Simren M, Tornblom H, Vanuytsel T, et al. Pathophysiological abnormalities in functional dyspepsia subgroups according to the Rome III criteria. Am J Gastroenterol. 2017;112:132–40.
Sugano K, Tack J, Kuipers EJ, Graham DY, El-Omar EM, Miura S, et al. Faculty members of Kyoto global consensus conference Kyoto global consensus report on helicobacter pylori gastritis. Gut. 2015;64:1353–67.
Walker MM, Aggarwal KR, Shim LS, Bassan M, Kalantar JS, Weltman MD, et al. Duodenal eosinophilia and early satiety in functional dyspepsia: confirmation of a positive association in an Australian cohort. J Gastroenterol Hepatol. 2014;29:474–9.
Lacy BE, Everhart K, Crowell MD. Functional dyspepsia is associated with sleep disorders. Clin Gastroenterol Hepatol. 2011;9:410–4.
Miwa H. Life style in persons with functional gastrointestinal disorders-large-scale internet survey of lifestyle in Japan. Neurogastroenterol Motil. 2012;24:464–71.
Li Y, Gong Y, Li Y, He D, Wu Y, Wang H, Cong X, Wei M, Lin L. Sleep disturbance and psychological distress are associated with functional dyspepsia based on Rome III criteria. BMC Psychiatry. 2018;18(1):–133.
Lanas A, Chan FKL. Peptic ulcer disease. Lancet. 2017 5;390(10094):613–624.
Cai H, Shu XO, Xiang YB, Yang G, Li H, Ji BT, Gao J, Gao YT, Zheng W. Sleep duration and mortality: a prospective study of 113 138 middle-aged and elderly Chinese men and women. Sleep. 2015;38(4):529–36.
Knutsson A, Bøggild H. Gastrointestinal disorders among shift workers. Scand J Work Environ Health. 2010;36(2):85–95.
Kato K, Murai I, Asai S, Takahashi Y, Nagata T, Komuro S, Mizuno S, Iwasaki A, Ishikawa K, Arakawa Y. Circadian rhythm of melatonin and prostaglandin in modulation of stress-induced gastric mucosal lesions in rats. Aliment Pharmacol Ther. 2002;16(Suppl 2):29–34.
Khanijow V, Prakash P, Emsellem HA, Borum ML, Doman DB. Sleep dysfunction and gastrointestinal diseases. Gastroenterol Hepatol (N Y). 2015;11(12):817–25.
Segawa K, Nakazawa S, Tsukamoto Y, et al. Peptic ulcer is prevalent among shift workers. Dig Dis Sci. 1987;32(5):449–53.
Fang B, Yang S, Xu R, Chen G. Association between poor sleep quality and subsequent peptic ulcer recurrence in older patients with mild cognitive impairment: examining the role of social engagement. Sci Rep. 2019;9(1):2188.
Lovell RM, Ford AC. Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis. Clin Gastroenterol Hepatol. 2012;10(7):712–721.e4.
Sperber AD, Dumitrascu D, Fukudo S, et al. The global prevalence of IBS in adults remains elusive due to the heterogeneity of studies: a Rome foundation working team literature review. Gut. 2017;66(6):1075–82.
Moayyedi P, Andrews CN, MacQueen G, Korownyk C, Marsiglio M, Graff L, Kvern B, Lazarescu A, Liu L, Paterson WG, Sidani S, Vanner S. Canadian Association of Gastroenterology clinical practice guideline for the management of irritable bowel syndrome (IBS). J Can Assoc Gastroenterol. 2019;2(1):6–29.
El-Salhy M. Recent developments in the pathophysiology of irritable bowel syndrome. World J Gastroenterol. 2015;21(25):7621–36.
Fass R, Fullerton S, Tung S, Mayer EA. Sleep disturbances in clinic patients with functional bowel disorders. Am J Gastroenterol. 2000;95:1195–2000.
Elsenbruch S, Harnish MJ, Orr WC. Subjective and objective sleep quality in irritable bowel syndrome. Am J Gastroenterol. 1999;94:2447–52.
Goldsmith G, Levin JS. Effect of sleep quality on symptoms of irritable bowel syndrome. Dig Dis Sci. 1993;38:1809–14.
Jarrett M, Heitkemper M, Cain KC, Burr RL, Hertig V. Sleep disturbance influences gastrointestinal symptoms in women with irritable bowel syndrome. Dig Dis Sci. 2000;45:952–9.
Vege SS, Locke GR 3rd, Weaver AL, Farmer SA, Melton LJ 3rd, Talley NJ. Functional gastrointestinal disorders among people with sleep disturbances: a population-based study. Mayo Clin Proc. 2004;79:1501–6.
Orr WC, Crowell MD, Lin B, Harnish MJ, Chen JD. Sleep and gastric function in irritable bowel syndrome: derailing the brain gut axis. Gut. 1997;41:390–3.
Tu Q, Heitkemper MM, Jarrett ME, Buchanan DT. Sleep disturbances in irritable bowel syndrome: a systematic review. Neurogastroenterol Motil. 2017;29(3) https://doi.org/10.1111/nmo.12946.
Wang B, Duan R, Duan L. Prevalence of sleep disorder in irritable bowel syndrome: a systematic review with meta-analysis. Saudi J Gastroenterol. 2018;24(3):141–50. https://doi.org/10.4103/sjg.SJG_603_17.
Lamb CA, Kennedy NA, Raine T, Hendy PA, Smith PJ, Limdi JK, Hayee B, Lomer MCE, Parkes GC, Selinger C, Barrett KJ, Davies RJ, Bennett C, Gittens S, Dunlop MG, Faiz O, Fraser A, Garrick V, Johnston PD, Parkes M, Sanderson J, Terry H, IBD guidelines eDelphi consensus group, Gaya DR, Iqbal TH, Taylor SA, Smith M, Brookes M, Hansen R, Hawthorne AB. British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults. Gut. 2019;68(Suppl 3):s1–s106. https://doi.org/10.1136/gutjnl-2019-318484. Epub 2019 Sep 27. Erratum in: Gut. 2021 Apr;70(4):1. PMID: 31562236; PMCID: PMC6872448
Sairenji T, Collins KL, Evans DV. An update on inflammatory bowel disease. Prim Care. 2017;44(4):673e92.
Bernstein CN, Loftus EV Jr, Ng SC, et al. Epidemiology and natural history task force of the international organization for the study of inflammatory bowel disease (IOIBD). Hospitalisations and surgery in Crohn’s disease. Gut. 2012;61(4):622e9.
Hommes D, Colombel JF, Emery P, et al. Changing Crohn’s disease management: need for new goals and indices to prevent disability and improve quality of life. J Crohns Colitis. 2012;6(Suppl 2):S224e34.
Mikocka-Walus A, Pittet V, Rossel JB, et al. Symptoms of depression and anxiety are independently associated with clinical recurrence of inflammatory bowel disease. Clin Gastroenterol Hepatol. 2016;14(6):829e35.
Ananthakrishnan AN, Khalili H, Konijeti GG, et al. Sleep duration affects risk for ulcerative colitis: a prospective cohort study. Clin Gastroenterol Hepatol. 2014;12:1879–86.
Graff LA, Vincent N, Walker JR, et al. A population-based study of fatigue and sleep difficulties in inflammatory bowel disease. Inflamm Bowel Dis. 2011;17:1882–9.
Swanson GR, Burgess HJ, Keshavarzian A. Sleep disturbances and inflammatory bowel disease: a potential trigger for disease flare? Expert Rev Clin Immunol. 2011;7:29–36.
Ali T, Madhoun MF, Orr WC, et al. Assessment of the relationship between quality of sleep and disease activity in inflammatory bowel disease patients. Inflamm Bowel Dis. 2013;19:2440–3.
Qazi T, Farraye FA. Sleep and inflammatory bowel disease: an important bidirectional relationship. Inflamm Bowel Dis. 2019;25(5):843e52.
Hao G, Zhu B, Li Y, Wang P, Li L, Hou L. Sleep quality and disease activity in patients with inflammatory bowel disease: a systematic review and meta-analysis. Sleep Med. 2020;75:301–8.
Acharya C, Bajaj JS. Current Management of Hepatic Encephalopathy. Am J Gastroenterol. 2018;113(11):1600–12.
Montagnese S, De Pittà C, De Rui M, et al. Sleep-wake abnormalities in patients with cirrhosis. Hepatology. 2014;59(2):705–12.
Bajaj JS, Thacker LR, Leszczyszyn D, et al. Effects of obstructive sleep apnea on sleep quality, cognition, and driving performance in patients with cirrhosis. Clin Gastroenterol Hepatol. 2015;13(2):390–397.e1.
Ghabril M, Jackson M, Gotur R, et al. Most individuals with advanced cirrhosis have sleep disturbances, which are associated with poor quality of life. Clin Gastroenterol Hepatol. 2017;15(8):1271–1278.e6.
Gencdal G, Gunsar F, Meral CE, et al. Sleep disorders in cirrhotics; how can we detect? Liver Int. 2014;34(8):1192–7.
Samanta J, Dhiman RK, Khatri A, et al. Correlation between degree and quality of sleep disturbance and the level of neuropsychiatric impairment in patients with liver cirrhosis. Metab Brain Dis. 2013;28(2):249–59.
Labenz C, Baron JS, Toenges G, et al. Prospective evaluation of the impact of covert hepatic encephalopathy on quality of life and sleep in cirrhotic patients. Aliment Pharmacol Ther. 2018;48(3):313–21.
De Rui M, Middleton B, Sticca A, et al. Sleep and circadian rhythms in hospitalized patients with decompensated cirrhosis: effect of light therapy. Neurochem Res. 2015;40(2):284–92.
Marques DM, Teixeira HR, Lopes AR, et al. Sleep quality assessment and daytime sleepiness of liver transplantation candidates. Transplant Proc. 2016;48(7):2356–60.
Morphy H, Dunn KM, Lewis M, Boardman HF, Croft PR. Epidemiology of insomnia: a longitudinal study in a UK population. Sleep. 2007;30(3):274–80.
Bersagliere A, Raduazzo ID, Nardi M, et al. Induced hyperammonemia may compromise the ability to generate restful sleep in patients with cirrhosis. Hepatology. 2012;55(3):869–78.
Bruyneel M, Sersté T, Libert W, et al. Improvement of sleep architecture parameters in cirrhotic patients with recurrent hepatic encephalopathy with the use of rifaximin. Eur J Gastroenterol Hepatol. 2017;29(3):302–8.
Montagnese S, Middleton B, Mani AR, Skene DJ, Morgan MY. Sleep and circadian abnormalities in patients with cirrhosis: features of delayed sleep phase syndrome? Metab Brain Dis. 2009;24(3):427–39.
Teodoro VV, Bragagnolo MA Jr, Lucchesi LM, et al. Polysomnographic sleep aspects in liver cirrhosis: a case control study. World J Gastroenterol. 2013;19(22):3433–8.
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Kumar, A., Saran, K., Gupta, R. (2022). Sleep Disturbances and Functional Gastrointestinal Diseases. In: Gupta, R., Neubauer, D.N., Pandi-Perumal, S.R. (eds) Sleep and Neuropsychiatric Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-16-0123-1_29
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